Using Systems Biology to understand Immunosenescen
  • Using Systems Biology to Understand Immunosenescence
  • Background
    • Introduction
    • 1.1. Aging in Society and in the Individual
    • 1.2. Aging and its Molecular Mechanisms
    • 1.3.The Remodeling of the Immune System: Immunosenescence
    • 1.4. Changes in the Immune System Related to Immunosenescence
    • 1.5 Chronic Inflammation During Aging: Inflammaging
    • 1.6 The Immune Risk Phenotype (IRP)
    • 1.6. Systems Biology
  • Objectives
  • Methods
    • Overall Methodology
    • 3.1 Survey of Studies
    • 3.2. Reannotation of Probes in Microarrays
    • 3.3. Data acquisition and pre-processing
    • 3.4. Creation of age-representative samples: AgeCollapsed
    • 3.5. Detection of Highly Age-Related Transcripts: AgingGenes
    • 3.6. Lifetime Co-Expressed Transcript Analysis: AgingNet
    • 3.7. Detection of Change Points in Age-Related Modules
  • Results
    • 4.1. Survey and Data Acquisition
    • 4.2. Reannotation of Platforms
    • 4.3. AgeCollapsed Pre-Processing and Creation
    • 4.4. Assessment of the Agreement of the Relationships of Transcripts with Age between the Sexes
    • 4.5. AgingGenes and AgingNet Reviews
    • 4.6 Aging Co-Expression Network: AgingNet
  • Discussion
    • Main Regards
    • AgingGenes
    • Análise de Co-Expressão: AgingNet
  • Conclusions
    • Final Regards
  • Citations
    • References
  • Appendix
    • Supplementary Files
Powered by GitBook