References

<a id="1">[1]</a> 
ACOSTA, J. C. et al. Control of senescence by CXCR2 and its ligands. Cell Cycle, v. 7, n. 19, p. 2956–2959, 13 Oct. 2008.

ALBANESE, D. et al. A practical tool for maximal information coefficient analysis. GigaScience, v. 7, n. 4, p. 1–8, 1 Apr. 2018. arrow-up-right

ANTONACI, S. et al. Non-specific immunity in aging: deficiency of monocyte and polymorphonuclear cell-mediated functions. Mechanisms of Ageing and Development, v. 24, n. 3, p. 367–375, Mar. 1984. arrow-up-right

BAKER, D. J. et al. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature, v. 530, n. 7589, p. 184–189, 11 Feb. 2016. arrow-up-right

BUFFA, S. et al. A novel B cell population revealed by a CD38/CD24 gating strategy: CD38(-)CD24 (-) B cells in centenarian offspring and elderly people. Age, v. 35, n. 5, p. 2009–2024, Oct. 2013. arrow-up-right

Carvalho-Bürguer, M - Análise Transcricional de RNAs Não Codificadores Longos em Pacientes com Dengue. Dissertação (Mestrado em Bioinformática) - Interunidades em Bioinformática, Universidade de São Paulo. São Paulo: 2017, 86p.

CAMPELLO, R. J. G. B.; MOULAVI, D.; SANDER, J. Density-Based Clustering Based on Hierarchical Density Estimates. In: PEI, J. et al. (Eds.). . Advances in Knowledge Discovery and Data Mining. Lecture Notes in Computer Science. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. v. 7819p. 160–172. arrow-up-right

CAMPISI, J.; D’ADDA DI FAGAGNA, F. Cellular senescence: when bad things happen to good cells. Nature Reviews. Molecular Cell Biology, v. 8, n. 9, p. 729–740, Sep. 2007. arrow-up-right

COLONNA-ROMANO, G. et al. B cell immunosenescence in the elderly and in centenarians. Rejuvenation Research, v. 11, n. 2, p. 433–439, Apr. 2008. arrow-up-right

COPPÉ, J.-P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biology, v. 6, n. 12, p. 2853–2868, 2 Dec. 2008. arrow-up-right

COPPÉ, J.-P. et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annual review of pathology, v. 5, p. 99–118, 2010. arrow-up-right

CRAN - Package TTR. Disponível em: <https://cran.r-project.org/web/packages/TTR/index.html>. Acesso em: 1 nov. 2018. arrow-up-right

CRIEL, J.; TSIPORKOVA, E. Gene Time E{chi}pression Warper: a tool for alignment, template matching and visualization of gene expression time series. Bioinformatics, v. 22, n. 2, p. 251–252, 15 Jan. 2006. arrow-up-right

CROFT, D. et al. Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Research, v. 39, n. Database issue, p. D691-7, Jan. 2011. arrow-up-right

DAVALOS, A. R. et al. Senescent cells as a source of inflammatory factors for tumor progression. Cancer metastasis reviews, v. 29, n. 2, p. 273–283, Jun. 2010. arrow-up-right

DAVIS, S.; MELTZER, P. S. GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor. Bioinformatics, v. 23, n. 14, p. 1846–1847, 15 Jul. 2007. arrow-up-right

DE MAGALHÃES, J. P.; TOUSSAINT, O. GenAge: a genomic and proteomic network map of human ageing. FEBS Letters, v. 571, n. 1–3, p. 243–247, 30 Jul. 2004. arrow-up-right

Density Based Clustering of Applications with Noise (DBSCAN) and Related Algorithms [R package dbscan version 1.1-2]. Disponível em: <https://cran.r-project.org/web/packages/dbscan/index.html>. Acesso em: 1 nov. 2018. arrow-up-right

DU, W. et al. TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. The Journal of Clinical Investigation, v. 116, n. 5, p. 1360–1370, May 2006. arrow-up-right

EDGAR, R.; DOMRACHEV, M.; LASH, A. E. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Research, v. 30, n. 1, p. 207–210, 1 Jan. 2002. arrow-up-right

ELZI, D. J. et al. Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Molecular and Cellular Biology, v. 32, n. 21, p. 4388–4399, Nov. 2012. arrow-up-right

FAUSTMAN, D. L.; DAVIS, M. TNF receptor 2 and disease: autoimmunity and regenerative medicine. Frontiers in immunology, v. 4, p. 478, 23 Dec. 2013. arrow-up-right

FLATT, T. A new definition of aging? Frontiers in genetics, v. 3, p. 148, 23 Aug. 2012. arrow-up-right

FREUND, A. et al. Inflammatory networks during cellular senescence: causes and consequences. Trends in Molecular Medicine, v. 16, n. 5, p. 238–246, 3 May 2010. arrow-up-right

FULOP, T. et al. Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? Frontiers in immunology, v. 8, p. 1960, 2017. arrow-up-right

GINALDI, L. et al. Immunosenescence and infectious diseases. Microbes and Infection, v. 3, n. 10, p. 851–857, Aug. 2001. arrow-up-right

GORGOULIS, V. G.; HALAZONETIS, T. D. Oncogene-induced senescence: the bright and dark side of the response. Current Opinion in Cell Biology, v. 22, n. 6, p. 816–827, Dec. 2010. arrow-up-right

GREGG, R. K. et al. A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes. Journal of Immunology, v. 173, n. 12, p. 7308–7316, 15 Dec. 2004. arrow-up-right

HARMAN, D. The free radical theory of aging: effect of age on serum copper levels. Journal of Gerontology, v. 20, p. 151–153, Apr. 1965. arrow-up-right

HARROW, J. et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Research, v. 22, n. 9, p. 1760–1774, Sep. 2012. arrow-up-right

HAYNES, L. et al. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proceedings of the National Academy of Sciences of the United States of America, v. 100, n. 25, p. 15053–15058, 9 Dec. 2003. arrow-up-right

Health and Economic Costs of Chronic Disease | About Chronic Disease | Chronic Disease Prevention and Health Promotion | CDC. Disponível em: <https://www.cdc.gov/chronicdisease/about/costs/index.htm>. Acesso em: 2 oct. 2018. arrow-up-right

HUBER, S. et al. Cutting edge: TGF-beta signaling is required for the in vivo expansion and immunosuppressive capacity of regulatory CD4+CD25+ T cells. Journal of Immunology, v. 173, n. 11, p. 6526–6531, 1 Dec. 2004. arrow-up-right

IBGE :: Instituto Brasileiro de Geografia e Estatística. Disponível em: <https://ww2.ibge.gov.br/home/estatistica/populacao/projecao_da_populacao/2013/default.shtm>. Acesso em: 2 oct. 2018. arrow-up-right

IRIZAR, H. et al. Age gene expression and coexpression progressive signatures in peripheral blood leukocytes. Experimental Gerontology, v. 72, p. 50–56, Dec. 2015. arrow-up-right

ITAKURA, F. Minimum prediction residual principle applied to speech recognition. IEEE transactions on acoustics, speech, and signal processing, v. 23, n. 1, p. 67–72, Feb. 1975. arrow-up-right

IYER, M. K. et al. The landscape of long noncoding RNAs in the human transcriptome. Nature Genetics, v. 47, n. 3, p. 199–208, Mar. 2015. arrow-up-right

JOHNSON, W. E.; LI, C.; RABINOVIC, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics, v. 8, n. 1, p. 118–127, Jan. 2007. arrow-up-right

KITANO, H. Systems biology: a brief overview. Science, v. 295, n. 5560, p. 1662–1664, 1 Mar. 2002. arrow-up-right

KOLESNIKOV, N. et al. ArrayExpress update--simplifying data submissions. Nucleic Acids Research, v. 43, n. Database issue, p. D1113-6, Jan. 2015. arrow-up-right

KUILMAN, T. et al. The essence of senescence. Genes & Development, v. 24, n. 22, p. 2463–2479, 15 Nov. 2010. arrow-up-right

KULESHOV, M. V. et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Research, v. 44, n. W1, p. W90-7, 8 Jul. 2016. arrow-up-right

LAGES, C. S. et al. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Journal of Immunology, v. 181, n. 3, p. 1835–1848, 1 Aug. 2008. arrow-up-right

LÓPEZ-OTÍN, C. et al. The hallmarks of aging. Cell, v. 153, n. 6, p. 1194–1217, 6 Jun. 2013. arrow-up-right

MAGGIO, M. et al. Interleukin-6 in aging and chronic disease: a magnificent pathway. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, v. 61, n. 6, p. 575–584, Jun. 2006. arrow-up-right

MANTON, K. G.; VAUPEL, J. W. Survival after the age of 80 in the United States, Sweden, France, England, and Japan. The New England Journal of Medicine, v. 333, n. 18, p. 1232–1235, 2 Nov. 1995. arrow-up-right

MANTOVANI, A.; ALLAVENA, P.; SICA, A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. European Journal of Cancer, v. 40, n. 11, p. 1660–1667, Jul. 2004. arrow-up-right

MATTHEWS, G. J.; FOULKES, A. S. MixMAP : AnR Package for Mixed Modeling of Meta-AnalysisValues in Genetic Association Studies. Journal of statistical software, v. 66, n. 3, p. 1–20, 2015. arrow-up-right

MUSZKAT, M. et al. Local and systemic immune response in nursing-home elderly following intranasal or intramuscular immunization with inactivated influenza vaccine. Vaccine, v. 21, n. 11–12, p. 1180–1186, Mar. 2003. arrow-up-right

NAKAMURA, K.; KITANI, A.; STROBER, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. The Journal of Experimental Medicine, v. 194, n. 5, p. 629–644, 3 Sep. 2001. arrow-up-right

NIKOLICH-ŽUGICH, J. The twilight of immunity: emerging concepts in aging of the immune system. Nature Immunology, v. 19, n. 1, p. 10–19, Jan. 2018. arrow-up-right

NOMELLINI, V.; GOMEZ, C. R.; KOVACS, E. J. Aging and impairment of innate immunity. Contributions to microbiology, v. 15, p. 188–205, 2008. arrow-up-right

PATEL, R. K.; MOHAN, C. PI3K/AKT signaling and systemic autoimmunity. Immunologic Research, v. 31, n. 1, p. 47–55, 2005. arrow-up-right

PICCOLO, S. R. et al. Multiplatform single-sample estimates of transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America, v. 110, n. 44, p. 17778–17783, 29 Oct. 2013. arrow-up-right

PRAKASH, S. et al. Impaired secretion of interferons by dendritic cells from aged subjects to influenza : role of histone modifications. Age, v. 35, n. 5, p. 1785–1797, Oct. 2013. arrow-up-right

PRITZ, T. et al. Plasma cell numbers decrease in bone marrow of old patients. European Journal of Immunology, v. 45, n. 3, p. 738–746, Mar. 2015. arrow-up-right

REED, S. M.; QUELLE, D. E. p53 acetylation: regulation and consequences. Cancers, v. 7, n. 1, p. 30–69, 23 Dec. 2014. arrow-up-right

REID, A. H.; TAUBENBERGER, J. K. The origin of the 1918 pandemic influenza virus: a continuing enigma. The Journal of General Virology, v. 84, n. Pt 9, p. 2285–2292, Sep. 2003. arrow-up-right

RESHEF, D. N. et al. Detecting novel associations in large data sets. Science, v. 334, n. 6062, p. 1518–1524, 16 Dec. 2011. arrow-up-right

RICCADONNA, S. et al. DTW-MIC Coexpression Networks from Time-Course Data. Plos One, v. 11, n. 3, p. e0152648, 31 Mar. 2016. arrow-up-right

RODIER, F.; CAMPISI, J. Four faces of cellular senescence. The Journal of Cell Biology, v. 192, n. 4, p. 547–556, 21 Feb. 2011. arrow-up-right

ROSENBERG, C. et al. Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen. Human vaccines & immunotherapeutics, v. 9, n. 7, p. 1466–1476, Jul. 2013. arrow-up-right

SCHWAIGER, S. et al. IL-4-producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. Journal of Immunology, v. 170, n. 1, p. 613–619, 1 Jan. 2003. arrow-up-right

SIMON, A. K.; HOLLANDER, G. A.; MCMICHAEL, A. Evolution of the immune system in humans from infancy to old age. Proceedings. Biological Sciences / the Royal Society, v. 282, n. 1821, p. 20143085, 22 Dec. 2015. arrow-up-right

STAHL, E. C.; BROWN, B. N. Cell therapy strategies to combat immunosenescence. Organogenesis, v. 11, n. 4, p. 159–172, 20 Nov. 2015. arrow-up-right

SZKLARCZYK, D. et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Research, v. 43, n. Database issue, p. D447-52, Jan. 2015. arrow-up-right

TURNER, H.; KINET, J.-P. Signalling through the high-affinity IgE receptor FcεRI. Nature, v. 402, n. 6760supp, p. 24–30, 25 Nov. 1999. arrow-up-right

UN. World population ageing 2015 highlights. [s.l.] United Nations, 2016. arrow-up-right

VALLEJO, A. N. CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunological Reviews, v. 205, p. 158–169, Jun. 2005. arrow-up-right

VAN DEURSEN, J. M. The role of senescent cells in ageing. Nature, v. 509, n. 7501, p. 439–446, 22 May 2014. arrow-up-right

VENTURA, M. T. Evaluation of IgA1-IgA2 levels in serum and saliva of young and elderly people. Allergologia et Immunopathologia, v. 19, n. 5, p. 183–185, Oct. 1991. arrow-up-right

visNetwork: Network Visualization using “vis.js” Library. Disponível em: <http://datastorm-open.github.io/visNetwork/>. Acesso em: 1 nov. 2018. arrow-up-right

VOLDERS, P.-J. et al. LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Research, v. 41, n. Database issue, p. D246-51, Jan. 2013. arrow-up-right

WEISKOPF, D.; WEINBERGER, B.; GRUBECK-LOEBENSTEIN, B. The aging of the immune system. Transplant International, v. 22, n. 11, p. 1041–1050, Nov. 2009. arrow-up-right

WEKSLER, M. E.; SZABO, P. The effect of age on the B-cell repertoire. Journal of Clinical Immunology, v. 20, n. 4, p. 240–249, Jul. 2000. arrow-up-right

WIKBY, A. et al. An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, v. 60, n. 5, p. 556–565, May 2005. arrow-up-right

XUE, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature, v. 445, n. 7128, p. 656–660, 8 Feb. 2007. arrow-up-right

ZHANG, B.; HORVATH, S. A general framework for weighted gene co-expression network analysis. Statistical Applications in Genetics and Molecular Biology, v. 4, p. Article17, 12 Aug. 2005. arrow-up-rightZHAO, Y. et al. NONCODE 2016: an informative and valuable data source of long non-coding RNAs. Nucleic Acids Research, v. 44, n. D1, p. D203-8, 4 Jan. 2016.arrow-up-right

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